Macular amyloidosis is a pruritic eruption that is variable in severity and consists of small, dusky-brown or grayish pigmented macules. Macular amyloidosis (MA) is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly. CASE REPORT. An unusual presentation of macular amyloidosis. Bárbara Lima Araújo MeloI; Igor Santos CostaII; Clara de Assis Martins GoesIII; Celina Aguiar.
|Published (Last):||18 November 2005|
|PDF File Size:||1.73 Mb|
|ePub File Size:||6.51 Mb|
|Price:||Free* [*Free Regsitration Required]|
In general, the treatment of PLCA is disappointing. Cutaneous amyloidosis associated with atopic disorders.
When stained with Congo red and viewed under polarized light, the amyloid substance exhibits amiloieosis birefringence. Nylon cloth macular amyloidosis. Amyloidosis is an extra-cellular deposition of the fibrous protein either involving multiple organ systems systemic amyloidosis or restricted to a single-tissue site localized amyloidosis.
Touart DM, Sau P. Histochemistry and electron microscopy. Journal of the American College of Cardiology. Materials and Methods Fifty patients with a clinical diagnosis of MA attending the out-patient clinic of a tertiary care dermatology center were enrolled in the study.
Similar observations were made in studies by Rasi et al. Bony prominences such as clavicular and scapular regions were involved in three patients each, with rare sites like the buttocks being involved in one patient.
The mean age of onset was Macular amyloidosis MA is a rare chronic form of cutaneous amyloidosis see this termmaculwr skin disease characterized by the accumulation of amyloid deposits in the dermis, clinically characterized by pruritic hyperkeratotic gray-brown macules that give a rippled or reticulated pattern of pigmentation usually in the upper back and extensor sites of arms, forearms and legs, and histologically by the deposition of amyloid in the upper dermis and close to the basal cell layer of the epidermis.
Lack amiloiosis clear-cut etiological factors makes it difficult to suggest a reasonable therapeutic modality. When signs and symptoms are evident, they depend on which of your organs are affected. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.
Nylon cloth macular amyloidosis.
Onset is typically during puberty, and the condition has an equal distribution between the sexes 2. Macular amyloidosis is one of the more common types of primary localized cutaneous amyloidoses. MA is commonly associated with other skin diseases, such as atopic dermatitis. Patient education is important in breaking the itch-scratch-itch cycle.
Click here for patient related inquiries. Home About Us Advertise Amazon. Click here for information on linking to our website or using our content or images. Contrary to previous reports, MA in our study was observed in a majority of patients of comparatively lighter skin than in those with a higher skin phototype.
There are also reports of rare hypochromic and poikilodermatous forms 4.
Primary cutaneous amyloidosis – Wikipedia
Family history is important because hereditary forms of macular amyloidosis do exist. The treatment for both macular amyloidosis and lichen amyloidosis tends to be grouped together in the literature with no uniformly effective therapy for these patients. J Am Acad Dermatol. YAG laser therapy for reduction of pigmentation in macular amyloidosis patches.
An overview of amyloidsosis. There is no convincing explanation for the origin of the amyloid protein in the skin. Accessed May 16, Fifty patients with a clinical diagnosis of MA attending the out-patient clinic of a tertiary care dermatology center were enrolled in the study. Cause – effect relationship?
Amyloidosis – Symptoms and causes – Mayo Clinic
These changes did not always correlate with the deposition of amyloid and extended well beyond the areas of amyloid deposits. Amyloid is macu,ar abnormal protein that is produced in your bone marrow and can be deposited in any tissue or organ. Various systemic and cutaneous diseases in association with MA in our patients were chronic urticaria, diabetes mellitus, acne vulgaris, generalized xeroderma, amiloidosus, hypertension and idiopathic hirsutism.
Rio Branco, 39 This content does not have an Arabic version.
This article has been cited by other articles in PMC. Overview Amyloidosis am-uh-loi-DO-sis is a rare disease that occurs when a substance called amyloid builds up in your organs.
Macular amyloidosis presenting in an incontinentia pigmenti-like pattern with subepidermal blister formation. Only comments written in English can be processed. This type of assessment is important as this condition has been associated with amyloidosis and multiple myeloma Notalgia paresthetica and Macular amyloidosis: If the condition affects nerves that control blood pressure, you may experience dizziness or near fainting when standing too quickly.
Treatment of cutaneous amyloidoses usually yields disappointing results. However, there is evidence linking primary localized cutaneous amyloidoses to a variety of immune disorders including systemic sclerosis, CREST syndrome, rheumatoid arthritis, systemic lupus erythematosus, primary biliary cirrhosis, autoimmune cholangitis, Kimura disease, ankylosing spondylitis, autoimmune thyroiditis, IgA nephropathy, and sarcoidosis.
Macular Amyloidosis (Friction Amhyloidosis)
The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. The use of nylon towels or brushes on the skin has also been described as a risk factor for the development of MA.
What is the Cause of the Disease?